I am a postdoctoral researcher in the Biophotonics Lab at the California Institute of Technology, under the supervision of Dr. Changhuei Yang. I received my B.S. in electrical engineering from Shanghai Jiao Tong University (2014) and my M.S. (2017) and Ph.D. (2022) in electrical engineering from Washington University in St. Louis. During my graduate studies, I worked in the Lew Lab and was advised by Dr. Matthew D. Lew. My research interests include single-molecule microscopy, computational imaging, and imaging system design.
News
2024/12
Our review paper entitled “Single-molecule orientation-localization microscopy: Applications and approaches” is published in Quarterly Reviews of Biophysics.
2024/08, updated 2024/09
Our collaborative work with the Newman Lab at Caltech entitled “Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopy” is now published in PNAS!
Press coverage here!
This work is covered by Science. Read it here!
2024/06
Our collaborative work with Mango Inc. is published in Biomedical Optics Express. Read it here:
Long-term imaging of three-dimensional hyphal development using the ePetri dish
2024/05
I gave an invited talk entitled “Six-dimensional nanoscopy for visualizing amyloid-membrane interactions” at the ARVO 2024 Annual Meeting in Seattle.
2024/01
I gave a talk entitled “Complex-field and fluorescence microscopy using aperture scanning technique (CFAST) for studying rhizosphere organisms” at 2024 SPIE Photonics West in San Francisco.
2024/01 Our news article, “Single-molecule orientation-localization microscopy,” is now online in Imaging & Microscopy.
2023/04, updated 2023/09
My mentee, Victoria Fay, has successfully defended her Master’s thesis, “Improving planar optodes lifetime: Encapsulation and optical release of pH sensing optodes and assessment of their lifetime in-situ.” Congratulations Victoria!
Victoria has won the Swiss Photonics Prize 2023, and her paper is published in Journal of Soils and Sediments. Read it here.
2023/03
I participated in a one-week workshop titled “Targeting Microhabitats for Life Detection - Part II,” hosted by the Keck Institute for Space Studies (KISS) at Caltech.
2022/12
Our collaborative work with the Vahey Lab at WashU Biomedical Engineering entitled “Six-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope” is now published in Nature Photonics!
Press coverage here!
2022/11
Our project on imaging the rhizosphere using an underground camera system has been featured in the Caltech magazine. Read it here!
2022/06
I joined the Biophotonics Lab at Caltech as a postdoc!
2022/04
I successfully defended my PhD dissertation!
I received the Department of Electrical and Systems Engineering’s Outstanding Doctoral Dissertation Award and was featured as an outstanding graduate by the McKelvey School of Engineering!
2022/01, updated 2022/05
Our paper entitled “Resolving the Three-Dimensional Rotational and Translational Dynamics of Single Molecules Using Radially and Azimuthally Polarized Fluorescence” is published in Nano Letters. Press coverage here!
2021/03
I gave a talk entitled “Measuring Single-Molecule Orientations Using a Radially and Azimuthally Polarized Epifluorescence Microscope” at Focus on Microscopy 2021.
2021/01
Our two-part series on fundamental limits and performance comparison of single-molecule orientation-localization microscopy are published in Journal of the Optical Society of America A. Read them here:
Single-molecule orientation localization microscopy I: fundamental limits
Single-molecule orientation localization microscopy II: a performance comparison (Editors’ Pick)
2020/11
I gave a talk entitled “Precision limits for measuring the 3D orientations of fluorescent molecules” at S3IC 2020: Single-Molecule Sensors and NanoSystems.
2020/07
Our paper on deriving the quantum limits of measuring molecular orientation is published in Physical Review Research. Read it here:
Quantum limits for precisely estimating the orientation and wobble of dipole emitters.
2020/04
I gave a talk entitled “Fundamental quantum bounds on the precision and accuracy of measuring molecular orientation” at the Computational Optical Imaging workshop at the IEEE ISBI 2020 virtual conference.
2019/04, updated 2019/08
Our paper entitled “Fundamental limits on measuring the rotational constraint of single molecules using fluorescence microscopy” is published in Physical Review Letters.
Press coverage here!